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The mechanisms of action of metformin
A review of 39 clinical studies found that IGF-1 and growth hormone administration showed increased bone resorption and bone formation
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The metanalysis includes 5,323 patients (56-61 years) with T2D inadequately controlled (HbA 1c 7-10.5%), baseline BMI 23-45 kg/m 2 , mean diabetes duration of 9-12 years, and randomized to receive a GLP-1RA or GIP/GLP-1RA versus placebo in add on to basal insulin for at least 24 weeks (24-40 weeks)
Nature 612(7941):739747
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